Case studies

Evidence-based formulations a different approach

Combination of two drugs: Two track development of an NCE and a known API.

Read More
Why integrated services benefit the project

In an ideal situation, a drug substance is developed, manufactured and then made available to a drug product/ formulation team…

Read More
When time is everything

A big pharma company’s CMO was hit with an import alert. This could have adversely impacted the market supply of…

Read More
Developing a safe and scalable drug substance

Enantiomerically enriched molecule entering phase III. Its synthesis involved pyrophoric reagents, labile liquid intermediate and potential genotoxic impurities

Read More
DoE and QbD based process development and manufacturing

Reduction of aromatic ring systems at elevated temperatures with large quantities of catalyst, long cycle time, control of unknown impurity…

Read More
Product development in a challenging IP landscape

Identifi­cation of suitable chiral reagent for chemical resolution, process validation, desired polymorph

Read More
Low yield challenges of atypical reaction

Seven stage sequence involving protection-deprotection sequence, labile intermediates and signi­cant by-product formation with low yield

Read More
How the re-designed synthesis of a complex carbohydrate can reduce cycle time.

Complex carbohydrate chemistry involving a linear sequence of 10 chemical transformations, unstable intermediates and column chromatographic purifications

Read More
Get In Touch

This website uses cookies to help us give you the best experience when you visit. By using this website you consent to our use of these cookies. For more information on our use of cookies, please review our cookie policy.