Publications

An efficient and convenient protocol for the synthesis of tetracyclic benzo [6,7] [1,4] oxazepino [4,5-a] quinazolin and benzo [5,6] [ 1,3] oxazino [3,4-a] quinazolin derivatives via intra molecular Aza Michael reaction

Narayana Murthy, S. Praveen Kumar, Satish P Nikumbh, L. Vaikunta Rao, Raghunadh. Akula.

RSC Advances, 2018, 8, 22331.

A convergent approach towards the synthesis of 2-alkyl-substituted tetrahydroquinoline alkaloid (–)-cuspareine.

V. Madhubabu, R. Shankar, T. Krishna, Y. Satish Kumar, Y. Chiranjeevi, Ch. Muralikrishna, H. Rama Mohan, Satish S. More, M. V. Basaveswara Rao, Raghunadh Akula.;

Tetrahedron: Asymmetry, 2017, 28, 1803.

A diastereoselective synthesis of boceprevir’s gem -dimethyl bicyclic [3.1.0] proline intermediate from an insecticide ingredient cis -cypermethric acid.

Srinivasa Reddy K. Vishnuvardhan Reddy E. Saikat Sen, Rajender D. Rajesh Kumar R. Sandip K. Vikas G, Malavika B, Rashid Abdul Rehman Khan, Manpreet Singh, Michael L, Bhaskar K. Moses Babu J. Pratap T. V. Siddaiah V. Javed Iqbal, Martin E. Fox, Vilas H. D. Srinivas O.

Tetrahedron 2017, 30, 4285-4294;

Synthesis of (+)-Patulolide C Using R-(+)-γ-Valerolactone as a Chiral Synthon.

Rajender Datrika, Srinivasa Reddy Kallam, Vikas Gajare, Sandip khobare, Veera swamy rama, Muralikrishna Kommi, Rama Mohan Hindupur, Siddaiah Vidavalur, T. V. Pratap.

ChemistrySelect 2017, 21, 5828-5831.

Development of a Chemoenzymatic Process for Dehydroepiandrosterone Acetate Synthesis.

Anna Fryszkowska, Justine Peterson, Nichola L. Davies, Colin Dewar, George Evans, Matthew Bycroft, Neil Triggs, Toni Fleming, Srikanth Sarat Chandra Gorantla, Garrett Hoge, Michael Quirmbach, Upadhya Timmanna, Srinivas Reddy Poreddy, D. Naresh Kumar Reddy, Vilas Dahanukar, Karen E. Holt-Tiffin.

Organic Process Research & Development,2016, 1520-1528.

A new strategy for accessing (S)-1-(furan-2-yl)pent-4-en-1-ol: a key precursor of Ipomoeassin family of compounds and C1–C15 domain of halichondrins.

Subba Rao Jammula, Venkateswara Rao Anna, Sudhakar Tatina, Thalishetti Krishna, B. Yogi Sreenivas, Manojit Pal

Tetrahedron Letters, 2016, 57, 35, 3924-3928.

Concise and highly stereoselective syntheses of D-fagomine and 2-epi-fagomine.

Srinivasa Reddy Kallam, Rajender Datrika, Sandip R. Khobare, Vikas S. Gajare, Nagaraju Rajana, H. Rama Mohan, J. Moses Babu, V. Siddaiah, T. V. Pratap.

Tetrahedron Lett. 2016, 56, 1351.

Stereoselective synthesis of R-(-) & S-(+)-phoracantholide I from R-(+)-γ-valerolactone.

Rajender Datrika, Srinivasa Reddy Kallam, Sandip R Khobare, Vikas S Gajare, Muralikrishna kommi, Ramamohan H, Siddaiah Vidavalur, Pratap T.V.

Tetrahedron: Asymmetry 2016, 14, 603-607.

A concise stereoselective synthesis of 1-deoxy-6-epi-castanospermine.

Vikas S. Gajare, Sandip R. Khobare, Rajender Datrika, K. Srinivasa Reddy, Nagaraju Rajana, B. Kishore Babu, B. Venkateswara Rao, U. K. Syam Kumar.

Tetrahedron Lett. 2016, 57, 1486–1488

One pot oxidative dehydration – oxidation of polyhydroxyhexanal oxime to polyhydroxy oxohexanenitrile: A versatile methodology for the facile access of azasugar alkaloids

Sandip R Khobare, Vikas Gajare, E. Vishnuvardhan Reddy, Rajender, Malavika Banda, V. Siddaiah, Upadhya Timanna, Vilas H Dahanukar, U. K. Syam Kumar.

Carbohydrate Research 2016, 435, 1.

Novel, Precise, Accurate Ion-Pairing Method to Determine the Related Substances of the Fondaparinux Sodium Drug Substance: Low-Molecular-Weight Heparin

Amol a. Deshpande, p. Madhavan, girish r. Deshpande, ravi kumar chandel, kaviraj m. Yarbagi, alok r. Joshi, j. Moses babu, r. Murali krishna, I. M. Rao

Sci Pharm. 2016; 84: 19–40

A cascade reaction for the new and direct synthesis of indolofuroquinoxaline.

Satish P. Nikumbh, Akula Raghunadh, T. Srinivasa Rao, V. Narayana Murthy, Suju C. Joseph, Y. L. N. Murthy and Manojit Pal.

RSC Adv., 2016, 6, 23489-23497

FeF3-catalyzed MCR in PEG-400: Ultrasound assisted synthesis of: N -substituted 2-aminopyridines.

Dinne naresh kumar reddy, Kothapalli bannoth chandrasekhar, Yaddanapudi sesha siva ganesh, G. Rajeshwar reddy, j. Pradeep kumar, Ravi kumar kapavarapu and manojit pal

RSC Adv., 2016,6, 67212-67217 

A concise approach to substituted Quinazolin-4(3H)-one natural products catalyzed by Iron(III) Chloride.

Ramamohan, M.; Raghavendrarao, K.; Sridhar, R.; Nagaraju, G.; Chandrasekhar, K. B.; Jayapraksh, S.

Tetrahedron Lett., 2016, 57, 1418-1420.

A cascade reaction for the new and direct synthesis of indolofuroquinoxalines.

Satish P. Nikumbh, Raghunadh Akula, V Narayana Murthy, Y. L. N. Murthy, Manojit Pal,

RSC Advances 2016, 5, 23489-23497.

A Simple Approach for the Synthesis of fused quinazoline based Tetracycliccompounds via MCR strategy

Narayana Murthy, Satish P Nikumbh, S. Praveen Kumar, L. Vaikunta Rao, Raghunadh Akula,

Synlett, 2016, 27, 2362-2367.

An efficient and convenient protocol for the synthesis of Tetracyclic Isoindolo [1,2-a]quinazolines Derivatives.

V. Madhubabu, R. Shankar, Satish.s.More, U. K. Syam Kumar, Mandava V. Basaveswara Rao, Raghunadh Akula

RSC Advances, 2016, 6, 36599-36601

Synthesis of 2-hydroxy-3-alkyl-2-phenyl-2, 3-dihydroquinazolin-4(1H)-one via molybdenum hexacarbonyl mediated CO gas-and ligand free carbonylative reactions

Subba Rao, T. Krishna; V. Narayana Murthy, J. Rajesh, A. Venkateswara Rao, aghunadh.Akula

RSC Advances, 2016,   6, 67534-67539

A short diastereostereoselective synthesis of cis-(2S,4S) and cis-(2R,4R)-4-hydroxyprolines.

Vikas S. Gajare, Sandip R. Khobare, B. Malavika, Nagaraju Rajana, B. Venkateswara Rao, U. K. Syam Kumar.

Tetrahedron Lett. 2015, 56, 3743-3746

Diversity oriented concise asymmetric synthesis of azasugars: a facile access to L-2,3-tran-3,4-cis-dihydroxyproline and (3S,5S)-3,4,5-trihydroxypiperidine.

Vikas S. Gajare, Sandip R. Khobare, Rajender Datrika, K. Srinivas Reddy, Nagaraju Rajana, Sarvesh Kumar, B. Venkateswara Rao, U. K. Syam Kumar.

Tetrahedron Lett. 2015, 56, 6659-6663.

Diastereoselective total synthesis of piperidine alkaloids: (2R,5R)-5-hydroxyhomopipecolic acid and (2R,5R,8R)-5-hydroxysedamine.

Sandip R. Khobare, Vikas S. Gajare, Nagaraju Rajana, Rajendra Datrika, K. Srinivas Reddy, U. K. Syam Kumar, V. Siddaiah.

Tetrahedron Lett. 2015, 56, 2207.

Formamide as an ammonia precursor: a catalyst-free rapid and practical synthesis of 2-substituted Quinazolin-4(3H)-ones leading to Luotonon B and E, Bouchardatineand 8-Norrutaecarpine.

Raghavendra Rao K, Raghunadh Akula,  Ramamohan M,  PraveenKumar S, Dipak K, Suresh Babu M,

RSC Advances , 2015, 5, 61575.

Sulphonic acid functionalized Wang resin (Wang-OSO3H) as polymeric acidic catalyst for the eco-friendly synthesis of 2,3-dihydroquinazolin-4(1H)-ones.

Dhanunjaya Rao A V , Vykunteswararao Rao B P ,  Nivrutti R  J, Dipak  K , Paul Douglas S, Raghunadh Akula.

Tetrahedron Letters, 2015, 56, 4714.

Simple and Highly Efficient Synthesis of Indolo- and Pyrrolo[1,2-a]quinoxalines Promoted by Molecular Iodine

Ramamohan, M.; Sridhar, R.; Raghavendrarao, K.; Naidu, P.; Chandrashekar, K.; Jayaprakash, S.

Synlett, 2015, 26, 1096-1100

An efficient one pot synthesis of 2-amino quinazolin-4(3H)-one derivative Via MCR strategy

Narayana Murthy, Satish P Nikumbh, S. Praveen Kumar, L. Vaikunta Rao, Raghunadh Akula,

 Tetrahedron Letters, 2015, 56, 5767-5770.

A greener approach towards double heteroarylation of N, O and S nucleophiles: synthesis of bioactive polynuclear fused N-heteroarenes.

Satish P. Nikumbh, Raghunadh Akula, V Narayana Murthy, Y. L. N. Murthy, Manojit Pal,

RSC Advances 2015, 5, 74570-74574.

A Practical Azide free Enantioselecive Synthesis of R-(+)- and S-(-)-3-Piperidinols.

Suresh Babu M,   Raghunadh Akula, Syam Kumar U. K,

Helvetica Chimica Acta, 2014, 97, 1507.

An oxidative amidation and heterocyclization approach for the synthesis of β-carbolines and dihydro eudistomin Y.

Suresh Babu M, Raghunadh Akula, Raghavendra Rao K, Syam Kumar U. K, Dubey P. K.

Beilstein. J. Org. Chem, 2014, 10, 471.

Synthesis of tetrahedral diaryl heptanoid ent-diospongin A and epimer-diospongin B by employing Julia–Kocienski olefination.

Suresh Babu M, Ramamohan M, Raghunadh Akula, Raghavendra Rao K, Vilas H. Dahanukar, Pratap T.V, Syam Kumar U.K, Dubey P.K,

Tetrahedron Letters, 2014, 55,  4739.

First Total Synthesis of N-(3-Guanidinopropyl)-2-(4-hydroxy phenyl) -2-oxoacetamide.

Satish S. M, Raghunadh Akula, Sankar R, Patel N.B, Dinesh S. B, Syam Kumar U.K,

Helvetica Chimica Acta, 2014, 97, 404.

Effect of Aqueous Polyethylene Glycol on 1,3-Dipolar Cycloaddition of Benzoylnitromethane/ Ethyl 2-Nitroacetate with Dipolarophiles: Green Synthesis of Isoxazoles and Isoxazolines.

R. Chary, G R, Reddy, Raghunadh Akula, T. Krishna, Manojit Pal.

Adv. Synth. Catal. 2014, 356, 160.

Applications of Gage Reproducibility & Repeatability (GRR): Understanding and Quantifying the Effect of Variations from Different Sources on a Robust Process Development.

Amol A. Deshpande, Ramya, A. Vishweshwar,V. Girish R. D.; Amrendra Kumar Roy.

Organic. Process Research &. Development, 2014, 1614–1621

A simple access to N-(un)substituted isoquinolin-1(2H)-ones: unusual formation of regioisomeric isoquinolin-1(4H)-ones

Gangadhara Chary, G. Dhananjaya, K. Vara Prasad, S. Vaishaly,Y. S. S. Ganesh, Balakrishna Dulla, K. Shiva Kumar and Manojit Pal,

Chem. Commun., 50, 2014, 6797

An efficient regioselective copper catalyzed multi-component synthesis of 1, 3- disubstituted pyrazoles.

Raghunadh Akula, Suresh Babu M, Ramamohan M, Raghavendra Rao K, Krishna T, Gangadhara Chary R, Vaikunta Rao L, Syam Kumar U.K,

Tetrahedron Letters, 2014, 55, 2986.

Diastereoselective total synthesis of 3,6-disubstituted piperidine alkaloids, (3R,6S)-epi-pseudoconhydrine and (3R,6R)-pseudoconhydrine.

Sandip R. Khobare, Vikas S. Gajare, Subbarao Jammula, U. K. Syam Kumar, Y.L.N. Murthy.

Tetrahedron Lett. 2013, 54, 2909.

Montmorillonite K-10 catalyzed green synthesis of 2,6-unsubstituted dihydropyridines as potential inhibitors of PDE4.

RamReddy, G. RajeshwarReddy, L. Srinivasula Reddy, Chandana Lakshmi T. Meda, Kishore V. L. Parsa, K. ShivaKumar, Y.Lingappa, ManojitPal

European Journal of Medicinal Chemistry, 2013, 395-404

Indion 860 catalyzed cascade reaction: a greener approach to functionalized cyclohexanones and their novel analogues.

Bhaskar Kumar, G. Dhananjaya, Ch. Sumanth, S. Vaishaly, Gajanan Botre, M. Srinivasa Rao, K. B. Chandra Sekhar, K. Shiva Kumar and Manojit Pal.

RSC Adv., 2013, 3, 2207-2210

Cu-catalyzed coupling-cyclization in PEG 400 under ultrasound: a highly selective and greener approach towards isocoumarins.

Gangadhara Chary, G. Rajeshwar Reddy, Y. S. S. Ganesh, K. Vara Prasad, S. K. Phani Chandra, Soumita Mukherjee and Manojit Pal,

RSC Advances, 3, 2013, 9641.

Synthesis of β-Arylacyl/β-Heteroarylacyl-β-alkylidene Malonatesand Their Application in Substituted Pyridone Synthesis.;

Manoj Balu Wagh, R. Shankar, K. Mini, T. Krishnamohan, M. V. Madhubabu, Abir K. Pal, Sarva Jayaprakash, T. Krishna, Vilas Dahanukar, U. K. Syam Kumar, C. H. Gill.;

J. Heterocyclic Chem., 2013, 50, 49

Synthesis of enantiomerically pure N-(2, 3-dihydroxypropyl) arylamides via oxidative esterification.

Raghunadh Akula, Satish S. M, Suresh Babu M, Vaikunta Rao L, Syam Kumar U. K,

Beilstein. J. Org. Chem, 2013, 9, 2129.

Synthesis of Isoquinoline Alkaloids via Oxidative Amidation–Bischler–Napieralski Reaction.

Shankar, Satish. S .More, M. V.Madhubabu, N. Vembu, U.K. Syam Kumar.;

Synlett., 2012, 6, 1013.

Construction of a quinoline ring viaa 3-component reaction in water: crystal structure analysis and H-bonding patterns of a 2-aryl quinoline

Ram Reddy, L. Srinivasula Reddy, G. Rajeshwar Reddy, Kaviraj Yarbagi, Y. Lingappa, D. Rambabu,G. Rama Krishna, C. Malla Reddy, K. Shiva Kumar and Manojit Pal

Green Chem., 2012,14, 1870-1872

Pd-mediated functionalization of polysubstituted pyrroles: Their evaluation as potential inhibitors of PDE4

Bhaskar Kumar, Ch. Sumanth, S.Vaishaly, M. Srinivasa Rao, K. B. Chandra Sekhar, Chandana Lakshmi T. Meda, Ajit Kandale, D. Rambabu, G. Rama Krishna, C. Malla Reddy, K. Shiva Kumar, Kishore V. L. Parsa, Manojit Pal,

Bioorganic & Medicinal Chemistry Letters, 22, 2012, 5639-5647.

(Pd/C-mediated)coupling–iodocyclization–coupling strategy in discovery of novel PDE4 inhibitors: a new synthesis of pyrazolopyrimidines.

Mahesh Kumar,  K. Siva Kumar,  Chandana L. T. Meda,  G. Rajeshwar Reddy,  Pradeep K. Mohakhud,  K. Mukkanti,  G. Rama Krishna, C. Malla Reddy,  D. Rambabu, K. Shiva Kumar,  K. Krishna Priya, Keerthana Sarma Chennubhotla, Rakesh Kumar Banote, Pushkar Kulkarni, Kishore V. L. Parsa and  Manojit Pa

Med. Chem. Commun., 2012,3, 667-672.

Construction of a six-membered fused N-heterocyclic ring via a new 3-component reaction: synthesis of (pyrazolo)pyrimidines/pyridinesw

Mahesh Kumar, K. Siva Kumar, Pradeep Kumar Mohakhud, K. Mukkanti, R. Kapavarapu, Kishore V. L. Parsa and Manojit Pal

Chem. Commun., 2012, 48, 431–433

An Efficient and Practical Synthesis of Aryl and Hetaryl ά-Keto Esters.

Raghunadh A, Suresh Babu M, Anil K.N, Santosh Kumar G, Vaikunta Rao L, Syam Kumar U. K,

 Synthesis, 2012, 44,283

A Concise and Convergent Synthesis of Luotonin B and E.

Manoj Balu Wagh, R. Shankar, U. K. Syam Kumar, C. H. Gill.

Synlett, 2011, 84-88

A Concise and Cascade Synthesis of Batracylin and Substituted Isoindolo-[1,2-b]quinazolin-12(10H)-ones.

Shankar, M. B. Wagh, M. V.Madhubabu, N. Vembu, U.K. Syam Kumar.;

Synlett., 2011, 23, 844

Synthesis of 5-Aryl and 5-Amidocamptothecins.

Suresh Babu M, Raghunadh Akula, Anil Kumar N, Syam Kumar U. K, Dubey P. K,

  1. Heterocyclic Chem, 2011, 48, 540.

Yb(OTf)3 catalyzed new cascade reaction: a facile assembly of fused quinazolinones

Siva Kumar, P. Mahesh Kumar,  M. Appi Reddy, Md. Ferozuddin, M. Sreenivasulu, Ahamed A. Jafar,  G. R. Krishna, C. Malla Reddy, D. Rambabu, K. Shiva Kumar, Sarbani Pale  and  Manojit Pal

Chem. Commun., 2011,47, 10263-10265

Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4.

Rajeshwar Reddy, T. Ram Reddy, Suju C. Joseph, K. Sateesh Reddy, L. Srinivasula Reddy, P. Mahesh Kumar, G. Rama Krishna, C. Malla Reddy, D. Rambabu, Ravikumar Kapavarapu, Chandana Lakshmi, Teja Meda, K. Krishna Priya, Kishore V. L. Parsad  and  Manojit Pal.

Chem. Commun., 2011,47, 7779-7781 

Regioselective alkynylation followed by Suzuki coupling of 2, 4-dichloroquinoline: Synthesis of 2-alkynyl-4-arylquinolines.

Ellanki A. Reddy, Aminul Islam, K. Mukkanti, Venkanna Bandameedi, Dipal R. Bhowmik and Manojit Pal

Beilstein Journal of Organic Chemistry 2009, 5, 32.

C-N bond forming under copper catalysis: a new synthesis of 2-substituted 5,6-dihydro-4-H-pyrrolo[3,2,1-ij] quinolones.

Mohosin Layek, A. V. Dhanunjaya Rao, Vikas Gajare, Dipak Kalita, Deepak Kumar Barange, Aminul Islam, K. Mukkanti, Manojit Pal.

 Tetrahedron Lett. 2009, 50, 4878-4881.

Pd/C-Cu in coupling–cyclization process: a general synthesis of 2-substituted oxopyrrolo[3,2,1-ij] quinolone derivatives.

Mohosin Layek, Vikas Gajare, Dipak Kalita, Aminul Islam, K. Mukkanti, Manojit Pal.

Tetrahedron Lett. 2009, 50, 3867-3871.

A highly effective synthesis of 2-alkynyl-7-azaindole: Pd/C-mediated alkynylation of heteroarylhalides in water.

Mohosin Layek, Vikas Gajare, Dipak Kalita, Aminul Islam, K. Mukkanti, Manojit Pal.

Tetrahedron 2009, 65, 4814-4819.

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